Vol. 3 No. 6 (2023)
Reimbursement Reviews

Axicabtagene Ciloleucel (Yescarta)

Published June 9, 2023

Key Messages

  • CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
  • The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
  • This review assesses axicabtagene ciloleucel (axi-cel; Yescarta), cell suspension in patient-specific single-infusion bag, target dose of 2 × 106 CAR-positive viable T cells/kg body weight to a maximum of 2 × 108 CAR-positive viable T cells, for IV infusion.
  • Indication: Treatment of adult patients with diffuse large B-cell lymphoma or high-grade B-cell lymphoma that is refractory to first-line chemoimmunotherapy or that relapses within 12 months of first-line chemoimmunotherapy.