Vol. 3 No. 8 (2023)
Reimbursement Reviews

Ciltacabtagene Autoleucel (Carvykti)

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Published August 2, 2023

Key Messages

  • CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
  • The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
  • This review assesses ciltacabtagene autoleucel (Carvykti), cell suspension in infusion bag, 0.5 × 106 to 1.0 × 106 CAR-positive viable T cells per kg body weight with a maximum of 1 × 108 CAR-positive viable T cells, for IV infusion.
  • Indication: For the treatment of adult patients with multiple myeloma, who have received at least 3 prior lines of therapy, including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody, and who are refractory to their last treatment.