Omaveloxolone (Skyclarys)

CDA-AMC

doi:10.51731/cjht.2025.1178

Vol. 5 No. 7 (2025)

Reimbursement Recommendations

Omaveloxolone (Skyclarys)

CDA-AMC

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DOI: https://doi.org/10.51731/cjht.2025.1178

Published July 28, 2025

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Key Messages

Canada’s Drug Agency (CDA-AMC) recommends that Skyclarys be reimbursed by public drug plans for the treatment of Friedreich’s ataxia (FA) if certain conditions are met.
Skyclarys should only be covered to treat patients aged 16 years and older, who have a confirmed genetic diagnosis of FA, and a score between 20 and 80 on the modified Friedreich’s Ataxia Rating Scale (mFARS). The mFARS scale measures how the disease affects bulbar function, coordination of the arms and legs, and balance.
Skyclarys should only be reimbursed if the patient is under the care of a clinician experienced in treating ataxias and if the cost of Skyclarys is reduced. Treatment with Skyclarys should be stopped if the patient’s mFARS score increases by more than 2 points in a year, or if their score increases to more than 80.

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